Ram-raiders targeted the Walton Centre as part of a failed cash machine attempt.
A red Land Rover was driven through the main sliding doors of the neurological hospital on Lower Lane during the incident at around 1.45am on Sunday.
Although damage was caused to the entrance, Merseyside Police confirmed that nobody was injured and the offenders left the scene empty-handed.
Detectives believe that those involved were targeting a cash machine on the hospital’s premises.
Three or four occupants of the vehicle were seen dressed in black and grey while wearing balaclavas and gloves as part of the attempted raid.
Detective Inspector Debbie Tipton said: “We initially believe that this was a failed attempt to ram the premises and steal the ATM machine, which is an incredibly risky and reckless thing to do.
“Thankfully, this attempt was unsuccessful and caused no injuries, but we are nonetheless determined to find those responsible and put them before the courts.
“The potential for serious injury and damage is clear, so help us remove these people from the streets.
“If you saw a red Land Rover or any other vehicles making off at speed in the area in the early hours, or if you have dashcam which may have captured something, let us know.
“A red Land Rover or another unfamiliar vehicle may have appeared in your street this morning, which could be vital in our investigation. Let us know and we will take action on all information provided.”
Anyone with information can contact @MerpolCC, call 101 with reference 0086, or you can call @CrimestoppersUK anonymously on 0800 555 111.