Liverpool will be without four players for their trip to face Watford.
Saturday’s lunchtime encounter at Vicarage Road marks Claudio Ranieri’s first outing since being appointed manager of the hosts in the international break.
But the Reds’ preparations for the game have suffered a series of setbacks with Alisson and Fabinho forced to miss out after their involvement for Brazil.
The pair will travel directly to Spain ahead of next week’s Champions League clash with Atletico Madrid in order to avoid the UK’s 10-day quarantine ruling.
Jurgen Klopp’s side are already set to be without Thiago Alcantara as he recovers from a calf problem picked up against Crystal Palace last month.
The Liverpool manager confirmed on Friday that fellow midfielder Curtis Jones is also sidelined with a groin problem picked up on England under-21 duty.
“When we talk about federations, Curtis Jones came back injured from the U21s. So, great. That’s not OK as well,” said Klopp.
“It’s really difficult to get proper contact even with the English federation, because they just do what they want.
“He didn’t train, was not involved in the first game, they didn’t do a scan.
“Then he played a few minutes in the second game, very important that he played there… came back, slight injury, not available for tomorrow.”