Liverpool is leading the way in the fight against cervical cancer.
Figures show 92% of 12 and 13-year-old girls have been vaccinated with the HPV jab compared with the 80.1% national average.
Liverpool Primary Care Trust School Health Manager Marie Tomlinson, who is leading the service, said: "We are delighted that so many girls in Liverpool received the vaccine in 2008/09, but we are aware that some work is still to be done to encourage those who choose not to receive the HPV vaccine to do so.
"Our challenge is even greater this year, so we would urge girls to accept the vaccine to guard themselves against cervical cancer."
Around 1,000 women die each year from cervical cancer, which is the second most common female cancer, affecting one in 145 women in the UK.
Big Brother star Jade Goody's high profile battle with the disease raised awareness of cervical cancer and led to the number of young women requesting smear tests increasing by a third.
The human papillomavirus (HPV) vaccine was introduced in autumn 2008 to protect against the two HPV types that cause more than 70% of cervical cancers.
It aims to save up to 400 lives every year.
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